The emerging role of histone demethylases in renal cell carcinoma
نویسندگان
چکیده
منابع مشابه
The Emerging Role of Histone Demethylases in Renal Cell Carcinoma
Renal cell carcinoma (RCC), the most common kidney cancer, is responsible for more than 100,000 deaths per year worldwide. The molecular mechanism of RCC is poorly understood. Many studies have indicated that epigenetic changes such as DNA methylation, noncoding RNAs, and histone modifications are central to the pathogenesis of cancer. Histone demethylases (KDMs) play a central role in histone ...
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Epigenetic information refers to heritable changes in gene function that are stable between cell divisions but which is not a result of changes in the DNA sequence. Part of the epigenetic mechanism has been ascribed to modifications of histones or DNA that affects the transcription of specific genes. In this context, post-translational modifications of histone tails, in particular methylation o...
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ژورنال
عنوان ژورنال: Journal of Kidney Cancer and VHL
سال: 2017
ISSN: 2203-5826
DOI: 10.15586/jkcvhl.2017.56